Rascal Flatts and Backstreet Boys will perform "What Hurts the Most" together at the 60th ACM Awards on May 8, with plans for additional surprises. The bands have a long history and mutual respect, with a collaborative version of the song now available. The live collaboration will be streamed on Prime Video at 8 p.m. ET, with Rascal Flatts' full duets album releasing on June 6.